说明: kchi1Education

2005-2008  M.Sc.    Computer Science & Technology,  Jilin University

2001-2005  B.A.      Computer Science & Technology,  Jilin University


Research Experience

  • Integrative analysis of schizophrenia and autoimmune diseases, to uncover their potentially common genetic mechanisms.
  • Network-based analysis of schizophrenia GWAS data to reveal its susceptibility genes.
  • Genome-scale metabolic network (GSMN) reconstruction. GSMNs were first reconstructed for a pathogen Burkholderia cenocepacia J2315 and for a beneficial bacterium, Sinorhizobium meliloti 1021.
  • Developed the database for genome polymorphism and gene function studies of Mycobacterium MyBASE. http://mybase.psych.ac.cn

    • Research Interest

  • Integration of genetic data, expression data and PPI network to explore the underlying mechanism for mental disorder.
  • To explore common genetic mechanisms between psychiatric disease and autoimmune disease.

    • Contact

    Phone:   86-10-64855841  Fax: 86-10-64855841

    Email:    fangkc@psych.ac.cn


    Publications: (* co-first author)

    1. Fang K., Zhang K., Wang J. (2015): Network-assisted analysis of primary Sjogren's syndrome GWAS data in Han Chinese. Scientific Reports, 5. doi: 10.1038/srep18855
    2. Chang S., Fang K. *, Zhang K., Wang J. (2015). Network-Based Analysis of Schizophrenia Genome-Wide Association Data to Detect the Joint Functional Association Signals. PLoS One, 10(7)
    3. Zhao, H., Li, M., Fang, K.*, Chen, W., & Wang, J. (2012). In silico insights into the symbiotic nitrogen fixation in Sinorhizobium meliloti via metabolic reconstruction. PLoS One, 7(2), e31287. doi: 10.1371/journal.pone.0031287
    4. 房柯池，王晶 (2011). 全基因组范围代谢网络的构建和最小基因组研究. 生命科学.
    5. Fang, K., Zhao, H., Sun, C., Lam, C. M., Chang, S., Zhang, K., Wang, J. (2011). Exploring the metabolic network of the epidemic pathogen Burkholderia cenocepacia J2315 via genome-scale reconstruction. BMC Syst Biol, 5, 83. doi: 10.1186/1752-0509-5-83.
    6. Zhu, X., Chang, S., Fang, K., Cui, S., Liu, J., Wu, Z., Wang, J. (2009). MyBASE: a database for genome polymorphism and gene function studies of Mycobacterium. BMC Microbiol, 9, 40. doi: 10.1186/1471-2180-9-40.