生物信息学实验室负责人

王晶 博士，研究员，博士生导师

王晶研究员致力于复杂疾病高通量、多组学数据的整合与挖掘，并以精神疾病为范例进行基于数据挖掘的分子遗传机制研究与生物标志物分析。迄今在重要学术刊物上发表论文近70篇（包括Nature、Science、Nature Genetics、Nature Review Genetics、Biological Psychiatry、Molecular Psychiatry、Nucleic Acids Research），其中第一和通讯作者论文40余篇。迄今发表文章累计影响因子逾500分，累计引用近万次。曾主持和参与科技部863项目、973项目、国家自然科学基金重大研究计划、创新群体项目、中国科学院知识创新工程重要方向项目、欧盟框架项目等累计近20项。

研究方向:

1. 生物数据库（大通量数据管理和挖掘）以及生物信息算法和工具的开发
2. 复杂疾病（专注自身免疫性疾病和神经精神类疾病）的遗传信息挖掘与分子机制研究

学术任职:

• 中国遗传学会国际交流委员会 委员
• 心理科学进展 编委
• 中国科学院科教融合卓越创新中心 岗位教授
• 中国科学院大学 岗位教授

联系方式:

• 电话：010-6485 5841
• 传真：010-6485 5841
• E-mail：wangjing AT psych.ac.cn （发送邮件时请将AT改成@）

代表论著:（# 通讯作者）

1. Yang, L., Chang, S., Lu, Q., Zhang, Y., Wu, Z., Sun, X., Cao, Q., Qian, Y., Jia, T., Xu, B., Duan, Q., Li, Y., Zhang, K., Gunter, S., Lu, L., Liu, D. #, Wang, J. #, Wang, Y. #, & Lu, L. (2017). A new locus regulating MICALL2 expression was identified for association with executive inhibition in children with attention deficit hyperactivity disorder. Mol Psychiatry. doi:10.1038/mp.2017.74


2. Guo, L., Du, Y., Qu, S., & Wang, J.# (2015). rVarBase: an updated database for regulatory features of human variants. Nucleic Acids Res. doi: 10.1093/nar/gkv1107


3. Chang, S., Fang, K., Zhang, K., & Wang, J.# (2015). Network-Based Analysis of Schizophrenia Genome-Wide Association Data to Detect the Joint Functional Association Signals. PLoS One, 10(7), e0133404. doi: 10.1371/journal.pone.0133404


4. Guo, L. Y., Du, Y., & Wang, J.# (2015). Network analysis reveals a stress-affected common gene module among seven stress-related diseases/systems which provides potential targets for mechanism research. Scientific Reports, 5. doi: Artn 12939 10.1038/Srep12939


5. Ott, J., Wang, J., & Leal, S. M. (2015). Genetic linkage analysis in the age of whole-genome sequencing. Nat Rev Genet. doi: 10.1038/nrg3908


6. Zhang, K.L.*, Chang, S.H.*, Guo, L.Y., Wang, J.#(2014) I-GSEA4GWAS v2: a web server for functional analysis of SNPs in trait-associated pathways identified from genome-wide association study. Protein & Cell. DOI 10.1007/s13238-014-0114-4


7. Guo, L.Y., Du, Y.,Chang, S.H., Zhang, W.N., Wang, J.# (2014). Applying differentially expressed genes from rodent models of chronic stress to researches of stress-related disease: an online database. Psychosomatic Medicine.


8. Guo, L., Du, Y., Chang, S., Zhang, K., & Wang, J.# (2014). rSNPBase: a database for curated regulatory SNPs. Nucleic Acids Res, 42 (D1): D1033-D1039. doi: 10.1093/nar/gkt1167


9. Li, Y. Z., Zhang, K. L., Chen, H., Sun, F., Xu, J. J., …Wang, J.# & Zhang, F., C. (2013). A genome-wide association study in Han Chinese identifies a susceptibility locus for primary Sjogren’s syndrome at 7q11.23. Nature Genetics doi:10.1038/ng.2779


10. Chang, S. H., Gao, L., Li, Z., Zhang, W. N., Du, Y., & Wang, J.# (2013). BDgene: A Genetic Database for Bipolar Disorder and Its Overlap With Schizophrenia and Major Depressive Disorder. Biol Psychiatry. doi: 10.1016/j.biopsych.2013.04.016